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34741

Phytochemical analysis and anticancer screening of some indigenous plants grown in Saudi Arabia

Article

Last updated: 22 Jan 2023

Subjects

-

Tags

Anti-cancer Immunotherapy

Abstract

This study was conducted to evaluate the phytochemical analysis, and in vitro anticancer screening of four wild plants grown in the northern region of the Kingdom of Saudi Arabia (KSA), namely: Convolvulus oxyphyllus, Rhazya stricta, Astragalus kahircus and Teucrium polium. Total phenolics content, flavonoids, anthocyanins, saponins, total antioxidant capacity (TAC) and 2,2-diphenyl-1picrylhydrazyl (DPPH) scavenging activity were assessed in their extracts. In vitro anticancer screening of the hydro-alcohol extracts was also assessed using human hepatocellular carcinoma (HepG-2) and breast adenocarcinoma (MCF-7) cell lines. The plant species revealed different metabolomic profiling. C. oxyphyllus showed the highest phenolic and flavonoids contents compared to other plant extracts. While, among these plant extracts, T. polium showed the highest level of TAC, saponins and anthocyanins contents. C. oxyphyllus showed the highest inhibition concentration 50% (IC50) against HepG-2 (18.8 μg/ml) and MCF-7 (4.1 μg/ml). The high-performance liquid chromatography ‎analysis of C. oxyphyllus extract revealed the presence of high content of benzoic acid and vanillic acid (phenolics) along with hesperidin (flavonoids). In conclusion, among the screened plants, C. oxyphyllus has the most potent anticancer activity against HepG-2 and MCF-7 cell lines in vitro

DOI

10.21608/jcbr.2019.34741

Keywords

Phytochemical, Anticancer, plant, extracts, HepG-2, MCF-7, cell lines

Authors

First Name

Sabry

Last Name

El-Naggar

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta 3111, Egypt

Email

sabry_elnaggar@yahoo.com

City

-

Orcid

0000-0002-7018-9350

First Name

Mousa

Last Name

Germoush

MiddleName

O.

Affiliation

Biology Department, College of Science, Jouf University, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Ibrahim

Last Name

Abdel-Farid

MiddleName

B.

Affiliation

Botany Department, Faculty of Science, Aswan University, Aswan 81528, Egypt

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Elgebaly

MiddleName

A.

Affiliation

Biology Department, College of Science, Jouf University, Kingdom of Saudi Arabia

Email

-

City

-

Orcid

-

First Name

Abdelhalim

Last Name

Alkhazendar

MiddleName

A

Affiliation

Department of quality education, Tanta Region of Al-Azhar, Tanta, Egypt.

Email

abdelhalimalkhazendar@gmail.com

City

-

Orcid

0000-0001-9427-5985

Volume

2

Article Issue

3

Related Issue

8315

Issue Date

2018-12-01

Receive Date

2018-07-16

Publish Date

2018-12-01

Page Start

1

Page End

9

Print ISSN

2682-261X

Online ISSN

2682-2628

Link

https://jcbr.journals.ekb.eg/article_34741.html

Detail API

https://jcbr.journals.ekb.eg/service?article_code=34741

Order

4

Type

Original Article

Type Code

885

Publication Type

Journal

Publication Title

International Journal of Cancer and Biomedical Research

Publication Link

https://jcbr.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023