A lot of several plants have therapeutic potentials. Some of these plants myrrha (Commiphora myrrha) belongs to Burseraceae family and samwah (Cleome droserifolia) belongs Cleomaceae family. These two plants were extracted with methanol. Methanolic extracts of these two plants were prepared. The extracts of myrrha and samwah plants were tested at different concentrations to know its ability to inhibit the growth of different tested fungi in two ways based on the estimation of mycelia dry weight in liquid media and the measurement of the diameter of the inhibition zone diameter of growth in solid media. Four microoraganisms were examined in this investigation. These fungal strains were: Aspergillus flavus, Aspergillus parasiticus, Aspergillus ochraceus and Fusarium moniliforme. Results indicated that terpenes, tannins, flavonoids, saponins, resins, alkaloids, resins, carbohyrates and phenolicglycosides were found in myrrha methanolic extract.However samwah contained the same components as myrrha except resins. Furthermore, various minerals were found in the extracts of the studied plants, including Ca, Mg, Fe, K, Zn, Mn,  Cu, Sr,  Ni,  B ,V, Ag ,Li  and Co .