During the two growing seasons 2020 and 2021, A field experiment was carried out at Sakha Agricultural Research Station, Kafr El- Sheikh Governorate, Egypt to assess the impact of individual or combination treatments (T1,T2,T3 and T4) of Plant growth promoting rhizobacteria (PGPR) and foliar spray with compost tea (CT) for enhancing vegetative growth, physiological characteristics, nutrient content and soil biological activities as well as yield components of rice plant (Sakha 105) grown under various intervals of irrigation water regime (I₁=irrigation every 3 days, I₂=irrigation every 6 days, and I₃=irrigation every 9 days). Results showed that all different irrigation water intervals accompanied with PGPR₊ CTtreatment gave the highest values of vegetative growth and physiological characteristics during the two seasons. At the flowering stage, leaves K⁺, K⁺/Na⁺ (%), Zn, Mn, Fe and Cu (mg Kg^-1) showed a significant increase when rice plants exposed to I₃ T₄ treatment, whereas there was a decrease in Na⁺ (%).  Similar trend was observed in the microbial communities in the rhizosphere of rice plants.  Soil enzymes were noted to increase with the combination treatment (PGPR + CT), at I₃ treatment compared to the other treatments, respectively. For yield parameters, irrigation treatments followed the order of I₁ > I₂ > I₃. However, it followed as T₄ > T₃ > T₂ > T₁ under soil and foliar spray treatments. Thus, combination treatment under different irrigation water intervals is an efficient way to partially get rid of the effects of drought on growth dynamics of rice.