At present, a great interest in establishing novel associations between higher plants and a variety of N₂-fixing microorganisms has entered the scientific scene arising from the prospects and the possibilities of their potentially application. . In this paper, data presented is obtained during the co-cultivation of local cyanobacteria strains previously isolated from the Egyptian rice soils and wheat. Results revealed that cyanobacteria inoculation (SBI) exhibited an economical view that it can save about 30 % of the mineral nitrogen amounts required for wheat crop production. This trend was noticed when SBI inoculation was applied at the rate of 3 kg ha^-1 combined with 80 kg N ha^-1 which recorded a grain yield not significantly different from that obtained by 120 kg N ha^-1 the recommended nitrogen dose in wheat cultivation. Cyanobacteria inoculated to wheat crop have also improved both wheat yield components and wheat grains quality.