Recently, a great attention is paid in establishing concept of the associations between wheat plants and a variety of N₂-fixing microorganisms. This phenomenon has entered the scientific scene arising from the prospects and the possibilities of their potentially application. . In this work, cyanobacteria inoculant (SBI) and the effective microorganisms (EM) were applied to wheat in a field experiment as single or dual inoculants under different levels of nitrogen. Results revealed that cyanobacteria inoculant (SBI) combined with EM application exhibited an economical view that it can save about 50 % of the mineral nitrogen amounts required for wheat crop production especially. The trend was noticed when SBI combined with EM which recorded a grain yield not significantly different from that obtained by the full recommended nitrogen dose in wheat cultivation. Wheat inoculation with cyanobacteria and EM as single or dual inoculants has also enhanced the NPK- uptake by wheat plant and wheat grains quality.