Two piles of banana trees residues inoculated with Trichoderma viride + Phanerochaete chrysosporium  were prepared  to get  a  C/N ratio of  30: 1 on dry weight basis , the first pile  received ammonium sulphate and superphosphate (compost A), the second pile was supplemented with cattle dung  at a ratio of  3 (banana trees residues) : 1 (cattle dung ) on dry weight basis to represent compost B. Both piles were composted aerobically for 16 weeks to obtain (compost A and compost B). Both composted materials (compost A & B) were applied in different treatments, i.e., Compost A and/or Compost B Plus NPK and Compost A or Compost B Plus NPK plus microbial inoculation (Azospirillum lipoferum + Bacillus circulans) in a pot experiment at a   rate of 3% (w/w on dry weight basis) using sandy soil to study their effect on the growth, NPK uptake of sorghum plants grown in the greenhouse for 8 weeks. Results indicate that the addition of both compost A & B combined with microbial inoculation increased both the growth and nutrients uptake of sorghum plants. .The highest increments of these tested parameters were achieved by compost B rather than compost A. On other hand, compost B showed a positive effect on soil NPK availability, which in turn enhanced NPK uptake by sorghum plants. Total count of bacteria, Azospirilla count and silicate bacteria count in soil as well as the availability of N, P and K were enhanced by organic manuring and microbial inoculation. Moreover, the addition of organic manure increased the soil organic matter and total N, P and K percentage, which lead to a slight decrease in soil pH and EC values. Therefore, adding banana trees residues compost to sandy soil in presence of chemical fertilizer combined with microbial inoculation could be recommended to be applied for sorghum to enhance growth and favorable nutrients uptake.