Salt stress considered one of the major environmental constraints to crop productivity worldwide. The present study was conducted to assess the ameliorative effects of potassium silicate (2% and 4%) and Nano NPK (50 and 100 ppm) exogenously applied such individually and combinations with salinity. NaCl (60, 120 mM) markedly inhibited the growth in pea (Pisum sativum L.) and increase chromosomal aberrations percentage. Thus, potassium silicate and Nano NPK markedly alleviated the salinity induced drastic effects on mitotic index, growth and productivity leading to reduce chromosomal aberrations.  In addition, Nano NPK and potassium silicate increased the leaf area, shoot length and number of leaves. This study recommends the application of potassium silicate and Nano NPK as a foliar spray for improving pea growth irrigated with salty water and increases the growth and productivity. This work investigated the biological effects of Nano NPK 100 ppm and 2% potassium silicate in vivo to improve the mitotic index and reducing chromosomal aberrations under salinity stress on plants.