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89428

THE EFFECT OF DIETARY SUPPLEMENTS WITH FOLIC ACID AND VITAMIN B12 ON PLASMA HOMOCYSTEINE LEVEL IN AN EGYPTIAN ELDERLY GROUP

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Last updated: 04 Jan 2025

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Abstract

 Elevated plasma total homocysteine (tHcy) concentrations have been confirmed as a risk factor for ischemic heart disease and other vascular disorders. High plasma homocysteine concentrations can be largely attributed to inadequate intake of folic acid and vitamin B12. On the other hand, data from several studies indicate that plasma homocysteine increases with age, independent of vitamin status. 56 subjects (30 males and 26 females) similar in socio-economic class (upper-middle), with an age range of 60– 70 years completed the study course. All were healthy working professionals. Clinical, nutritional and anthropometric evaluations were carried out. Biochemical analysis for blood homocysteine, vitamin B12 and folic acid were performed. All the evaluated parameters were performed at the beginning of the study and after four months of supplementation with biscuits and dietary intake rich in vitamin B12 and folic acid. The results of study show that before the supplementation, the plasma homocysteine level was 13.8 ± 2.2 μmol-1 this level was significantly high, which indicating a state of mild hyperhomocysteinemia, then returned to its normal values after four months of supplementation with increased dietary intake of vitamin B12 and folic acid. Significant decrease in plasma tHcy and increase in vitamin B12 and folic acid levels is recorded after the four months of supplementation P (< 0.01). In conclusion, the daily consumption of B12 and folic acid supplements appears to be the most effective factor for reducing tHcy concentration. As a result vitamin B12 and folic acid supplementation for elderly is recommended

DOI

10.21608/jacb.2010.89428

Keywords

Homocysteine, Supplementation, Folic acid, Vitamin B12

Authors

First Name

Mona

Last Name

Hussein

MiddleName

M.

Affiliation

Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt

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First Name

Sorya

Last Name

El-Damhougy

MiddleName

T.

Affiliation

Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt

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City

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Orcid

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First Name

Abeer

Last Name

Afify

MiddleName

A.

Affiliation

Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt

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Orcid

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First Name

Madiha

Last Name

Abd El-Kader

MiddleName

M.

Affiliation

Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt

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Orcid

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First Name

Seham

Last Name

Kasam

MiddleName

S.

Affiliation

Food Science and Nutrition Department, National Research Center, Dokki, Cairo, Egypt

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Volume

1

Article Issue

5

Related Issue

13445

Issue Date

2010-05-01

Receive Date

2010-05-01

Publish Date

2010-05-01

Page Start

241

Page End

249

Print ISSN

2090-3626

Online ISSN

2090-3707

Link

https://jacb.journals.ekb.eg/article_89428.html

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https://jacb.journals.ekb.eg/service?article_code=89428

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Original Article

Type Code

883

Publication Type

Journal

Publication Title

Journal of Agricultural Chemistry and Biotechnology

Publication Link

https://jacb.journals.ekb.eg/

MainTitle

THE EFFECT OF DIETARY SUPPLEMENTS WITH FOLIC ACID AND VITAMIN B12 ON PLASMA HOMOCYSTEINE LEVEL IN AN EGYPTIAN ELDERLY GROUP

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Article

Created At

22 Jan 2023