Crude methanoilc extracts of thompson seedless, flame seedless, zizyphus, pomegranate and fig leaves were prepared. In this work the efficiency of the investigated extracts has been studied to elucidate their activities on some blood constituents of diabetic rats. The most effective treatment was the methanolic extract of zizyphus leaves which decreased blood glucose level to 128.33mg/dl at a dose of 40mg/100g body weight after 30 days where the maximum reduction of about 66.95% was obtained comparing with control diabetic rats. Whereas treatments of streptozocin diabetic rats with methanolic extract of thompson seedless leaves resulted the maximum percentage of reduction in ALT activity with 60.91% after 30 days by using 40mg/100 body weight. Extract of flame seedless leaves was the most effective for reduction of AST enzyme with a percentage of 46.23% after 30 days when 40mg/100 body weight was used. Serum creatinine and urea levels were affected by the methanolic leaves extract of thompson seedless to achieve the maximum reduction of 51.36 and 39.64% comparing with control diabetic rats at a dose of 40mg/100g body weight for 30 days. Also, lipid profile (triglycerides, total cholesterol, HDL, LDL and vLDL) were affected with treatment by the methanolic leaves extract with different values.