This research was achieved during the summer seasons 2018 and 2019 at El Baramoon Horticulture Research Farm, Dakahlia Governorate. Four parental lines of cantaloupe (Cucumis melo, L) were evaluated in this investigation to genetic analysis to identify suitable parents for development and relase of new cantaloupe. The results found that some F₁ hybrids exhibited highly significant for mid parents and better parents heterosis for traits. High estimated heterosis was reflected by four F₁ and F_1r hybrid, i.e., P₁ X P₄, P₁ X P₂, P₃ X P₄ andP₂ X P₁ for most traits. GCA, SCA and reciprocal effects were significant for studied traits. Parent P₄ was the better combiner for all traits exclude days to anthesis of first female flower. However, parent P₁ was the better combiner for days to anthesis of first female flower. The values of additive genetic variance o²A were higher than those of non - additive genetic variance (o²D) for all studied traits exclude days to anthesis of first female flower, pointing to the additive gene effect played the important role in the inheritance of studied traits. In addition, the values of broad sense heritability were higher than narrow sense heritability for studied traits. Genotypic and phenotypic correlations were positive and significant among total yield and some related traits such as fruit flesh thickness, average fruit weight and number of fruits per plot exhibited that each trait could be used indirectly to selection of yield. Hence, it could be suggested that these hybrids may be desirable parents for development new promising hybrids of cantaloupe.