The effectiveness of honeycomb pedigree selection (HPS) as compared to conventional pedigree selection (CPS) and mass selection (MS) were studied in one interaspecific cross between two promising hybrids Giza84 × ( Giza74  × Giza 68) and Giza 77 × Pima S₆  . Combined selection for yield and lint quality traits was applied for three cycles. Finally, the best F₅ lines derived by each method were tested in comparative experiments as randomized complete blocks design with three replications at Sakha Agric. Res. Station (2010). The analysis of variance indicated significant differences among of the selected lines for seed cotton yield and other traits except, for mean of boll weight. No significant differences were found between overall means of two groups CPS and HPS. In contrast, the mean of lines derived from third method MS . No significant differences however, were identified between the selected lines of the two methods ( HPS and CPS ) for lint quality traits. On the basis of mean seed cotton yield, boll weight, lint percent and fiber length as well as number of superior lines derived by each method.  It was concluded that HPS was effective than CPS and MS in identifying lines with high yielding ability and a good lint quality. This superiority of HPS is attributed at least partially to its effectiveness in early segregating generation selection.