During the successive seasons (2008-09 and 2009 -10) wheat field experiments were carried out at EL- Ismailia Agriculture Research Station Agric. Res. Center (ARC) to study the effect of cyanobacteria inoculation and/or effective microorganisms and mineral nitrogen fertilizer on wheat plants (Sakha 69). In this work, cyanobacteria inoculation and the effective microorganisms (EM) were applied to wheat each alone or both in combination under different levels of nitrogen, i.e., ¹/₄, ¹/₂ and full N recommended dose). Results revealed that cyanobacteria inoculation combined with EM application exhibited an economical view that it can save about 50 % was noticed when cyanobacteria combined with EM which recorded a grain yield not significantly different from that obtained by the full recommended nitrogen dose in wheat cultivation. Cyanobacteria inoculation to wheat crop along with EM have also enhanced the NPK- uptake by wheat plant, the soil microbial community, wheat grains technology, dehyderogenase activity and Co₂ evolution as index of soil fertility.