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48462

EFFECT OF CRUDE METHANOLIC EXTRACTS OF SOME MEDICINAL PLANT FLOWERS ON SOLID EHRLICH TUMOR IN MICE.

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Last updated: 22 Jan 2023

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Abstract

Crude methanolic extracts of Cynara Cardunculus, Achillea millefolium, Calendula officinalis, and Matricaria chamomilla flowers belong to family Compositeaewere used in this work to study their efficiency to relief solid ehrlich tumor in mice. The more effective extract was with that of C. officinalis which decreased tumor size from 513.6 to 124.5mm at a dose of 200mg/kg body weightcomparing with doxorubicin which reduced tumor size to 98.2mm in concentration of 15mg/kg after 21 days, followed by M. chamomilla which showed the mean value of 157.1mm. While,the lowest values were with C. cardunculus and A. millefolium flowers extract which were 184.3 and 210.9 mm, respectively. Also, the more effective treatment weredoxorubicin in concentration of 15mg/kg and C. officinalis, followed by M. chamomilla, C. cardunculus and A. millefolium flowers methanolic extract for blood tests in tumor mice, e.g. antioxidant markers (MDA, TAC, SOD), liver functions (ALT, AST, Total proteins, Albumin and Globulins), kidney functions (Creatinine and Urea) lipid profile (triglycerides, total cholesterol, HDL, LDL and vLDL) haematological parameters (HB, RBCs, Plt and WBCs),comparing with control tumor mice at a dose of 200mg/kg body weight for 21 days.

DOI

10.21608/jacb.2015.48462

Keywords

medicinal plants and solid ehrlich ascitic tumor

Authors

First Name

N. S.

Last Name

Erian

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Affiliation

Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt.

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First Name

H. B.

Last Name

Hamed

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Affiliation

Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt.

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Orcid

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First Name

A. Y.

Last Name

El-Khateeb

MiddleName

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Affiliation

Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt.

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Orcid

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First Name

M.

Last Name

Farid

MiddleName

-

Affiliation

Dept. of Agric. Chemistry, Faculty of Agriculture, Mansoura University, Egypt.

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Volume

6

Article Issue

11

Related Issue

7535

Issue Date

2015-11-01

Receive Date

2015-11-20

Publish Date

2015-11-01

Page Start

559

Page End

578

Print ISSN

2090-3626

Online ISSN

2090-3707

Article File

JACB_Volume 6_Issue 11_Pages 559-578.pdf

PDF . 602.3kB

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https://jacb.journals.ekb.eg/article_48462.html

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https://jacb.journals.ekb.eg/service?article_code=48462

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Original Article

Type Code

883

Publication Type

Journal

Publication Title

Journal of Agricultural Chemistry and Biotechnology

Publication Link

https://jacb.journals.ekb.eg/

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Created At

22 Jan 2023