Silkworm(Bombyx mori.), It is an important economic insect which is a producer of silk. Flacherie is a pattern associated with bacterial diseases on silkworm. The incidence of diseases at the time of silkworm rearing severely reduces the production of silk. This study was designed to examine the possibility of controlling the bacterial diseases in silkworm using the ethanolic extracts of propolis and cinnamon oil extract. The infected larvae were collected and the pathogenic bacteria were isolated and identified. Antibacterial activity of two extracts was tested in Muller Hinton agar plates with the concentrations of 0, 20, 50, and 100 µl. The sensitivity rate was much effective in ethanolic extract of propolis than cinnamon oil extract in vivo and in vitro. Therefore, It can be used for controlling bacterial disease (flacherie) and improve larvae health, its weight and cocoon weight which lead to increase the silk production.