An experiment was conducted to determine the efficiency of banana peel to reduce the toxic effect of aflatoxins (AFS) in male albino rats. Seventy eight male albino rats were assigned to 13 experimental diets.  The first one served as control received basal diet only, the second served as control DMSO (basal diet and 5ml DMSO /kg B.W.) daily, but the third and fourth one were received 1mg and 2mg AFs/ml respectively. The three following groups were received basal diet only supplemented with banana peel in percentage of 1,2 and 3%,then three groups received basal diet and orally (1mg AFS suspended in 5ml DMSO /kg B.W.) low dose of aflatoxins with the same levels of banana peel. The last three groups received basal diet and orally (2mg AFS suspended in 5ml DMSO /kg B.W.) high dose of aflatoxins with the same levels of banana peel .The duration of this experiment was 6 weeks. Results showed that, albino rats received 38mg and 76mg/kg aflatoxins revealed a significant elevation in the serum levels of AST, ALT, ALP, creatinine, urea, cholesterol and triglyceride, while decrease in total protein (TP) and albumin. Results of hematological parameters showed decrease in red blood cells (RBCs), hemoglobin (HB), packed cell volume (PCV), mean Corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) and platelets while increase in total leucocyte count (TLC).Body weights and organ weights were determined to study its changes. The treatments with banana peel can play a practical role in detoxification of aflatoxins in albino rats.