This study was undertaken to assess the effect of Glycyrrhiza glabra root extract (GGE)  on the plasma lipid profile of rats. Thirty male albino rats weighing between 150 g and 170 g were used for this investigation. Rats fed 150, 250 and 400 mg/kg (GGE)  for a period of 60 days showed significantly (p < 0:05) decreased the levels of total cholesterol (TC),total low density lipoprotein (LDL)   and total triglycerides (TG) cholesterol on the other hand increased the level of high density lipoprotein (HDL) cholesterol in compared with positive control fed high cholesterol diets HCD.