Epidemic disease with hepatitis C virus (HCV) was raised by scanty immune restraint. Empirical facts propose that low activation of TLRs 2-4 sensors participates to epidemic disease. We predestined the allocation of Single nucleotide Polymorphism (SNPs) in the TLR2 Arg677Trp in epidemic HCV disease and minus HCV sets. This research purposes to discuss the modulation of genetic ethnic polymorphisms of TLR2 gene in the epidemic HCV disease Egyptian positive HCV.  TLR2 Arg677Trp rs121917864 (C/T) were genotyped in 549 positive HCV and 519 negative HCV sets. The combination analysis proved that the having of rare allele T of TLR2 Arg677Trp could have a low significant risk for epidemic HCV disease (OR= 1.5206 95%CI 1.1521 to 2.0069) and P = 0.0031.