In this study the effect of garlic and coriander extract in comparison to albendazole against experimental infection of Haemonchus contortus (H. Contortus) in sheep was evaluated. Sheep were divided into 5 groups; the 1^st one represented control negative. The remaining groups were infected orally with 1750 H. contortus infective larvae (L3) and were equally subdivided into control positive (infected untreated), infected and treated orally with garlic (5ml/animal), infected and treated orally with coriander extract (0.9g/ kg b.w.) and infected and treated orally with Albendazole (10 mg/ kg b.w). The treatments were done on the 4^th and 6^th week post infection. Fecal samples were collected weekly after 3 weeks post infection for Fecal Egg Count (FEC). Blood samples were collected at the 5^th till the 8^th  week post infection. Coriander and garlic treated sheep expressed a significant reduction in FEC compared to the control positive. While in albendazole treated group, FECs was zero at the 7^th and 8^th weeks post infection. Erythrogram showed normocytic normochromic anemia at the 5^thand 6^th week and normocytic hypochromic anemia at the 7^th and 8^th week in infected groups. Significant increase in total peroxide, malondialdehyde (MDA), protein carbonyl (PC), Nitric oxide (NO), and total free amino acids (TFAA) levels with significant decrease in reduced glutathione (GSH) and superoxide dismutase (SOD) values of all treated groups when compared to control negative one. Garlic and coriander treatments showed ameliorative effect as they decrease the levels of total peroxide, MDA, PC, NO and TFAA. Also, garlic, coriander and albendazole showed an improving effect on the levels of SOD when compared to control positive group. In conclusion, sheep nematodiasisis accompanied by disturbances in protein synthesis combined with a general state of oxidative damage. Moreover, garlic and coriander showed animproving effect on the antioxidants alterations in experimentally infested sheep with haemonchosis.