One hundred faecal samples and buccal swabs were collected from 80 diseased and 20 healthy turkey birds in private farms (25 from each, 20 diseased and 5 heathy). Parasitological examination revealed that the infection rate among the diseased birds was 40% (32 out of 80), and 55% (11 out of 20) among the healthy birds. Single and mixed infections were 68.75%, 31.25%, 45.45% and 54.55% in diseased and health birds respectively. Ascaridia galli, Eimeria meleagrimitis and Tritrichomonas eberthi were the internal parasites identified in the study. Infected turkeys showed a significant decrease in RBCs, Hb, serum iron, calcium, sodium and potassium levels coupled with leucocytosis, lymphocytosis, heterophilia, eosinophilia, basophilia, and monocytosis compared with healthy turkeys group. Many pathological lesions in gastro-intestinal tracts were detected as well. Flubendazole, Toltrazuril and Metronidazole were the drugs which have 100% efficiency against the mentioned parasites and consequently lead to the improvement of the hematological and mineral picture as well as the pathological lesions.