In this study, we overviewed the influences of orally provided bee pollen (BPO) and Mannan-oligosaccharides (MOS) suspension on the biochemical, hematological and immunity parameters and antioxidant activity of growing rabbits. Rabbits of 35 days of age weight (751.8±68.8 g) were distributed into four groups (20 rabbits per group); control group; bee pollen (200 mg/kg BW), MOS (35 mg/kg BW) and a combination group (BPO+MOS) for eight weeks. MOS treated group with significantly increased PCV in comparison with BPO and BPO with MOS. Group treated with combination BPO with MOS had the highest WBCs in comparison with the other treatments and control. The treated rabbits with MOS significantly increased glucose levels, while the means of cholesterol significantly decreased less than the control group. BPO and MOS had a significantly higher T3 hormone in comparison to the control group. The treated rabbits with BPO and MOS had significantly decreased liver enzymes and urea less than those of the control group. Furthermore, Rabbits treated with BPO and/or MOS also showed decreased malondialdehyde, but increased total antioxidant capacity and phagocytic activity. Conclusively, adding BPO and MOS to growing rabbits enhances cell-mediated immune response, hematological and biochemical parameters reflecting and raising immunity and antioxidative responses.