Daily drenching of propylene glycol to buffalo cows in early lactation was used aiming at improving the reproductive performance through increasing plasma glucose and insulin . Twenty two buffalo cows were assigned to two groups (treated and control). Treated buffaloes were given a daily oral dose of propylene glycol from day 7 to day 40 postpartum. Plasma concentrations of glucose. insulin, and urea were measured once weekly during 2-9 weeks postpartum. and progesterone concentrations were measured twice weekly from 2 to 13 weeks postpartum. Propylene glycol increased plasma glucose concentrations in treatment group (63.06 i 0.34 vs. 6016 t 0.67 mgrdl), and increased insignificantly insulin concentrations in treated buffaloes compared with control group. Plasma urea nitrogen (PUN) in the control group tended to be higher than that in the treatment group (37.21 i 0.23 vs. 35.9? 2 0.16 mgl‘dl}. The interval from calving to first ovulation in the treatment buffaloes were less than that in the control buffaloes. Days open period was less in treated group than that in the control (65.45 i 7.5 vs. 8181 t 8.2 days). Conception rates at 50 days postpartum were 36% in the treated group and 18% in the control group. These results demonstrate that. administration of propylene glycol may improve ovarian function during early postpartum period in buffalo.