The present study showed the effect of feeding lettuce and garden rocket to diabetic rats on some biochemical indices. Diabetic rats fed experimental diets for 28 days including lettuce, garden rocket or their mixture presented a gradual increase of relative liver, kidney and spleen weight. Serum level of calcium, phosphorus, magnesium, zinc, iron, ferritin and blood hemoglobin and hematocrit, were also increased. Rats fed experimental diets showed a gradual decrease of blood and liver cholesterol, triglycerides, phospholipids, free fatty acids, AST, ALT, ALP, creatinine, urea and blood glucose, while HDL-cholesterol increased.