A total number of 210 Sina layers (28 week of age) were used to study the effect of substituting yellow corn (YC) by rice bran (RB) at different levels on laying hen performance with reference to antioxidant (AX) supplementation. The experiment included 7 treatment groups. Three experimental diets without antioxidant supplementation were formulated in which rice bran replaced control ration at levels of 7.5, 15 and 22.5 %. The other corresponding three diets had BHT antioxidant at the level of 500mg/kg. Layer groups were given diets containing 16% CP and 2700 Kcal. MElKg at the experimental period (20 weeks). The following results were obtained: 1. Rice bran could substitute YC in Sina layer diets up to the rate of 22.5% without harmful effects on egg number (EN), egg weight (EW), egg mass (EM), feed conversion (FC), egg quality, fertility, hatchability and decreased Yolk cholesterol value too. 2. Antioxidant supplementation resulted in slight improvements in EN, EW, EM, FC, fertility, hatchability and yolk cholesterol.