The present study was carried out in Hadraba valley, Halayib and Shalateen Research Station, belonging to Desert Research Center, South of Egypt. The study aimed at standing on the effects of changes in seasonal environmental conditions, on physiological, hemato-biochemical responses and growth efficiency of growing kids throughout different seasons of the year.Kids crop of eighty female Baladi goats were distributed randomly in the four seasons of the year (20 does! each). Changes allover the four seasons in climatic data were studied along with live body weight. Physiological responses, (rectal temperature (RT), respiration rate (RR) and heart rate (HR) ) , hematological responses ( hemoglobin (Hb). packed cell volume (PCV)) and some blood components. ( total serum protein (TP), albumin (AL), globulin (GL), albumin 1 globulin (NG) ratio, aspartate aminotransferase (AST), alanine aminotransferase (ALT), glucose, sodium (Na), potassium (K), calcium (Ca), phosphrus (P) and magnesium (Mg) ) were also studied . The environmental conditions were found to be hot along spring, summer and autumn, while winter could be considered as a temperate season. relative humidity was low most of the year. The highest overall means of RT, RR and HR of kids were in the hot seasons (summer and spring and autumn), while the lowest one were at the cold season (winter) . Parameters increased to the plateu level on the days 15 and 30 of age and then decreased significantly with advancing age. Hemoglobin increased in winter season than in summer .The PCV values showed an oppisit trend. Age significantly affected the Hb and PCV values.The values of TP were higher in spring and summer than in winter and autumn. In winter, the GL decreased: while the AL increased. The trend was reversed in summer. Age showed no significant effect on TP, AL, GL and NG ratio. The higher overall mean of AST was in spring followed by autumn and summer; the lowest one was in winter. The higher overall mean of ALT was in summer, while the lowest value was in winter. Age significantly (P<0.01) affected AST and ALT levels in blood. Kids showed higher glucose level in spring and summer than in winter and autumn. Glucose level in blood was the highest (P:0.01) at birth, then decreased gradually up to weaning. Levels of blood Na and K showed higher (P<0.01) values in summer. autumn and spring than in winter season. In the same time levels of Ca and P showed an opposite trend. Meanwhile, Mg did not differ due to season. Only Ca and P increased with advancing age. Season and sex significantly affected birth and weaning weights and daily gain. It can be concluded that in Hadraba valley, the hot conditions of summer season exerted heat stress on thermal balance of kids. Moreover, the kids had signs of hemoconcentration during summer. Additionally, liver enzymes increased in summer. Spring season could be considered the best season for raising kids in this region as they showed highest birth and weaning weights and the lowest mortality rate from birth to weaning age In this area.