The present study was aimed to investigate the effect of supplemented 3 different commercial probiotics and multi-enzyme commercial in adequate diets on locally produced mule ducks performance during the growing period (6 to 11 weeks of age). A total number of 150 mule ducks at 6 weeks of age, were randomly distributed into five dietary treatments. All diets were equal in all nutrients (18.6%, CP and ME, 3028 kcal / kg diet). The five treatments were: (T1) basal diet (control), basal diet supplemented with multi-enzyme commercial T-protphyt (T2), basal diet supplemented with commercial probiotic and prebiotic Biomin® Impo (T3), basal diet  supplemented with probiotic Primalac® (T4), and basal diet supplemented with probiotic Wazn Zad (T5). Live body weight, body weight gain, feed intake, feed conversion ratio, protein efficiency ratio, efficiency of energy utilization, and growth performance index were measured weekly and the entire experimental period. Body measurements (shank length, keel length, and breast  circumference) and the correlation between live body weight and body measurements were also measured. At the end of study some blood constituents ]cholesterol, triglycerides, high-density lipoprotein cholesterol(HDL), low-density lipoprotein cholesterol (LDL), very low-density lipoprotein cholesterol  (VLDL), total protein, albumin, globulin , albumin/globulin ratio, AST, and ALT [  and economic efficiency were quantified. The obtained results can be summarized as follows: at 11weeks of age dietary treatments had no significant effects on live body weight, weight gain, feed intake, feed conversion ratio, protein efficiency ratio, efficiency of energy utilization, growth performance index and body measurements. Pearson correlation coefficient between live body weight and shank length, keel length, and breast circumference was significant (p ≤0.01). No significant differences among treatments in cholesterol, triglycerides, high-density lipoprotein cholesterol  (HDL), low-density lipoprotein cholesterol (LDL), and very low-density lipoprotein cholesterol  (VLDL), total protein, albumin, globulin , albumin/globulin ratio, AST, and ALT. All treatments improved the economic efficiency insignificantly as compared to control diet. Although no significant difference between groups due to the type of feed additives concerning growth performance treats, it was observed that using Biomin Impo and Wazn Zad showed better economic efficiency amounted to 29.5 and 25 % respectively in comparison to control group.