Thirty, nine month old, male Bouscat rabbits were used in this research to study the long-term ,15 wks, effects of testosterone propionate (TP) or human chorionic gonadotropin (hCG) administration on reproductive performance. Rabbits were randomly divided into five equal groups (6 males each) and housed individually in standard batteries. The first two groups were injected with TP (5 and 10 mg/kg/day) while the other three groups were injected with hCG (200, 400 and 800 IU/animal/day). Semen was collected weekly using the artificial vagina and evaluated during the pre (3wks) and post (15 wks) treatment. The criteria under study were: reaction time, ejaculate volume, motility, sperm concentration/mm³ and seminal fructose level.                 The results showed no significant differences between all treatments in the reaction time and also pre and post treatments. TP administration resulted in impaired motility in both doses, while there were no obvious trends in all hCG doses. There were a highly significant differences (P<0.01) in ejaculate volume in both treatments due to the increase in gel part. Sperm concentration showed significant decrease in number at the end of the experiment to reach 10% of the pre-treatment values. Both doses of TP administration didn't result in any significant increase in fructose level in the liquid part of semen.  Similarly, medium and high doses of hCG  had no effect on fructose level. In contrast, the low dose of hCG resulted in significant increase in fructose secretion after the fifth week of injection.  In conclusion, hCG can be more safe for treatment or use than TP. Therefore, additional precautions should be considered with TP usage. .