This study was conducted to investigate the effect of feeding diets containing probiotics for 28 days during summer and winter seasons on thermo- cardio- respiratory responses as well as hematological parameters of Hassani goats raised under the conditions of El-Shalateen- Halaieb- Abo Ramad triangle. Twenty Hassani goats Bucks (aged18-24months) with average body weight 20.45±0.355 kg. were used. Animals were divided randomly into two equal groups. The first group served as a control group. The other group was fed a diet supplemented with probiotics (10 g/ head/ day; Biovet- YC). Meteorological data in terms of ambient temperature (AT) and relative humidity (RH) were recorded. In addition, thermo- cardio- respiratory responses in terms of rectal (RT), skin (ST) temperatures, respiration (RR) and heart (HR) rates were recorded twice daily at 08.00 and 14.00 hrs. Likewise, hematocrit percentage (Ht), hemoglobin concentration (Hb) and erythrocytes count (RBC's) were determined. The mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were calculated. The results revealed that, thermo- cardio- respiratory responses, Hb, Ht, RBC's and MCV were higher (P<0.01) in summer than in winter season. However, the mean values of MCHC and MCH in winter season exceeded those recorded in summer (P<0.01).   Probiotics supplementation reduced significantly (P<0.01) the mean values of RT and RR, while HR was not significantly changed. In addition,  the mean value of ST was increased (P<0.05) by feeding probiotics. Furthermore, feeding diets with probiotics increased RBC's (P0.01), Ht (P<0.05) and Hb while reduced MCH (P<0.01), MCV and MCHC. It is worthy to confirm that the improvement observed in the thermo- respiratory responses due to probiotics supplementation was more pronounced in summer season than in winter season but for the hematological parameters, it was more obvious in winter season than in summer season. It could be concluded that probiotics supplementation might be an avenue for animals raised in such desert conditions to improve their thermal and hematological ability.