The present study was carried out at Maryout Research Station (32˚n latitude, 35 km southwest of Alexandria) which belongs to the DesertResearchCenter, Ministry of Agriculture and Land Reclamation. Ten male Syrian Gabaly goats, aged 2 months on average were used to study the effects of seasonal climatic changes on some physiological and blood biochemical parameters throughout a year in such newly reclaimed area.  Results demonstrated that season had a significant effect on RT, ST, RR and CT goats. The highest overall mean value of rectal temperature was observed in summer followed by winter, autumn and spring, respectively, while spring had the highest values of skin and coat temperatures. The higher value of respiration rate was recorded in summer followed by spring season, especially in the afternoon, which indicated that this parameter was more affected by the ambient temperature. The mean values of the physiological responses of goats during different seasons showed a trend of increase from CT via ST to RT, and it also increased from 08.00 hr to 14.00 hr parallel to increasing AT. Season had a significant effect on plasma concentrations of TP, A, G and plasma concentrations of T₄ while it did not affect T₃ levels in goats. In summer, the kids had the highest values of total protein, albumin and globulin. The A/ G ratio did not significantly vary among seasons. The lowest concentrations of T₃ and T₄ were recorded in summer, while the highest values were observed in spring and winter, respectively. It could be concluded that season had a significant effect on the thermo-respiratory responses and some blood biochemical parameters under consideration of the growing male Syrian Gabaly goats, which in turn may associate with the change in thyroid gland activity.