This study was assigned to evaluate the effect of water deprivation on physiological responses, liver and kidney functions, hematological parameters, serum metabolites, electrolytes and hormonal profiles of Baladi goats during summer months. A total of 12 healthy, non-pregnant and non-lactating does (1.5-2 years old) were divided into 2 groups (average body weight of 23.35±1.16 and 23.15±1.13 kg for control and the treated group (exposed to water deprivation cycles 24h, 48h and 72h /week for 3 months. Temperature-humidity index (THI) was determined. Rectal temperature (RT) and respiration rate (RR) were measured. Haematological parameters, serum hormones, metabolites and electrolytes were assayed. Results showed that RT was higher (P≤0.05) in deprived does for 48h and 72h, but 24h did not affect RT compared with control. RR reduced insignificantly, but BW decreased (P≤0.05) in deprived does. Water deprivation had no effect (P>0.05) on haematological parameters, liver and kidney functions (ALT, AST, urea, creatinine). Each of total proteins, globulin, cholesterol and triglycerides increased (P≤0.05), while albumin insignificantly increased in deprived does. Serum glucose had reduced (P≤0.05) as water deprivation progressed. Serum electrolytes differed (P≤0.05), except for Cl^- . Content of Na⁺ and Cl^- increased, while K⁺ decreased in deprived does (P≤0.05). Serum Aldosterone and IgG levels increased (P<0.05) in deprived does, however, no significant effect on thyroid hormones. It is concluded that Baladi goats could be adapted for unsuitable conditions of water insufficiency or drought without having harmful effects.