The recent study was outlined to explore the effects of added prebiotics (Agri-MOS) on growth performance, carcass characteristics, blood constituents and oxidative status of NZW rabbits. A total number of 75 (42-days old) NZW rabbits were randomly divided into 5 groups; each group included 5 replicates of 3 rabbits each. Rabbits were reared in metallic batteries under comparable management circumstances and fed 5 pelleted diets similar in all nutrients content from 6 to 13 weeks old. Agri-MOS was supplemented to the experimental diets at zero (control), 0.25, 0.50, 0.75 and 1.00 g/kg diet, respectively. The experimental groups of rabbits subjected either to 0.75 or 1.0 g Agri-MOS addition achieved significantly higher live body weight and percentage of empty carcass compared to other treatments. Rabbits group fed 1.0g Agri-MOS-supplemented diet had the lowest count of Esherichia coli. However, Lactobacillus spp. of cecal contents was higher in the groups fed Agri-MOS-supplemented diets compared to the control group. Blood plasma content of glucose, total protein, albumin, lipids profile, liver and kidney function, oxidative status and thyroid hormones of growing NZW rabbits were significantly affected by feeding Agri-MOS-supplemented-diets. In conclusion, dietary Agri-MOS supplementation up to 1.0g/kg diet enhanced productive performance, oxidative status, cecum microbial counts and histomorphological section of rabbit cecal, without unfavorable effect on the physiological responses of NZW rabbits.