This study was  conducted to study the effect of dietary supplementation of silver nanoparticles (90 nm in size) on growth performance, nutrient utilization, proximate composition, certain biochemical , antioxidant and immunity  parameters and histopathologicalexaminationof sex reversed (all males) Nile tilapia (Oreochromis niloticus). Three treatments (Control, Sliver NPS   0.04 & 0.08 mg / kg diet). were triplicated and a total number of 288 fish Nile tilapia (56 ± 0.1 g / fish) were stocked in nine concrete ponds (1x4x1m). Fish were fed with 30% crude proteincommercial diet (gross energy 4120.7 Kcal/kg). Triple times a day fish were fed for 8 weeks at 3% of their body weight. The obtained results presented an enhanced Impact of silver nanoparticles (AgNPS) on growth, response of immunity, as antioxidants, and resistance to Aeromonas hydrophila infection in O. niloticus. Thus, Ag NPs are recommended to be used for improving growth, immunity, antioxidative responses and controlling A. hydrophila infection in Nile tilapia.