This experiment was conducted at RegionalCenter for Food and Feed (RCFF), to determine the capability of tilapia, Oreochromis niloticus, to utilize high levels of dietary lipid in compensation for the poor quality of dietary protein. Three types of dietary protein quality were used, the first type contained 18% fish meal, the second type contained 9% fish meal and the third one composed of plant ingredients. Each type of feed was supplemented with corn oil to contain either 5% or 12% lipid. These experimental diets were fed for 7 weeks to triplicate groups of tilapia. Weight gain was not statistically different (p ≥ 0.05) among the experimental groups of fish. Feed conversion, was statistically affected (p ≤ 0.05) by increasing dietary lipid at the whole plant ingredient diets. The efficiency by which the feeds were converted into live weigh gain indicated that increasing lipid levels in tilapia, Oreochromis niloticus, feeds up to 12% did not economically reduce the feeding cost of one Kg of fish.