A plant protein mixture (PPM) was tested to replace fish meal (FM) in diets for juvenile mono sex Nile tilapia, Oreochromis niloticus. Fish averaging (± SD) 3.27 ± 0.1 g were divided into 15 groups. Three groups were fed each of five isonitrogenous (30.4%) and isocaloric (4.7 kcal g ^{-- 1}) diets replacing 0, 25, 50, 75, and 100% of fish meal protein with similar percentages of PPM (PPM 0, PPM25, PPM50, PPM75, or PPMI00, respectively). The PPM consisted of 25% peanut meal, 25% okara meal, 25% canola meal and 25% corn glutein meal. After 10 weeks of feeding, fish fed diets PPM50 exhibited growth performance and feed utilization not significantly different from fish fed control diet which contained 100% fish meal protein. Incorporation of plant protein mixture in mono sex Nile tilapia diets significantly decreased moisture, protein and fat content of whole body. The highest value of lipid content was recorded with fish fed 100% plant protein mixture meal (Diet 5) and the lowest was recorded with fish fed 100% FM protein (control, Diet 1). Based on the results of this study PPM diets were economically superior to FM diet. Therefore, these findings suggest that up to 50% of fish meal protein can be replaced by plant protein mixture in mono sex Nile tilapia diets without any adverse effects on growth performances, feed utilization and body composition.