Aflatoxins (AFs) are acutely toxic, carcinogenic, mutagenic, teratogenic and immunosuppressive to most mammalian species. AFs contamination of food and live stock feeds is an ongoing problem. Punica granatum L. (pomegranate) is an important source of bioactive compounds and has been used for folk medicine for many centuries. The aim of our study was to examine the potential protective effect of pomegranate peel (PP) powder against toxic effect of AFs on body organs of guinea pigs (GPs). 105 male GPs were divided into 15 groups. 1^st group received basal diet (control G₁). 2^nd group received low dose of AFs  (25 µg/kg diet), 3^rd group received high dose of AFs (50 µg/kg diet) , while 4^th, 5^th, 6^th, 7^th groups received 6%, 9%, 12%, and 15% of PP powder in diet respectively, 8^th, 9^th, 10^th, 11^th groups received 6%, 9%, 12%, and 15% of  PP  powder plus low dose of AFs  respectively in diet, while 12^th, 13^th, 14^th, 15^th groups received 6%, 9%, 12%, and 15% of PP powder plus high dose of AFs  respectively in diet. Histopathological examination of liver, kidney and brain was proceeding at 10^th and 30^th day post treatment. Results revealed that AFs cause sever damage of liver, kidney and brain in time and dose dependant manner, while there are no pathological lesions found in groups treated by PP powder. More over all PP concentration showed protective activity against liver damage in GPs treated by low dose of AFs and reduce effect of high dose of AFs on liver in concentration dependant manner. Also pomegranate peel has protective effect against kidney and brain damage especially at low dose of AFs but there is no difference between PP concentrations in ability of protection of brain. While higher dose of PP showed more protective effect than lower concentration against kidney toxicity by high dose of AF.