The current experiment was directed to examine the beneficial impacts of dietary enrichment with commercial probiotics (Provilacc) on performance, Biochemical profile, oxidative status and Immunological response, antibody titers against avian flu virus (AFV) and Newcastle disease virus (NDV) in chickens. In this experiment, 200 day- old unsexed Hubbard broilers were randomly distributed to four equal experimental groups (0.0, 0.5, 0.75 and 1.0 g Provilacc /kg diet) , each of which include 5 equal replicates. High level of commercial natural growth promoters were (1.0 g/kg diet) had a positive effect on LBW, BWG and FCR whilst feed intake was slightly enhanced comparison with the control one. Also, Blood plasma concentrations of cholesterol (Chol), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL) had differed significantly between the control and provilacc-supplemented groups. Also, provilacc supplementation in the diet could improve thyroid function. In addition, supplementing provilacc had a significant positive effect on liver function (AST, ALT and AlkP), SOD, MDA and antibody titers against NDV and AFV. The outcome of the present work show that adding provilacc (commercial natural growth promoters) to diets of Hubbard chicks up to 1.0g/kg diet has a helpful effect on oxidative status and Immunological response, antibody titers against avian flu virus (AFV) and Newcastle disease virus (NDV) under normal conditions.