Objective of this study was to explore the impact of adding El-Mufeed liquid to salt tolerant plants in an attempt to reduce the oxidative stress of these plants by detecting changes in antioxidant indicators such as  malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX (in Shami goats during pregnancy under South Sinai semi-arid conditions, Egypt. Two equal experimental groups (12 does each) were used. The first control group was fed wheat straw as the roughage portion of the diet, while the second group was fed salt tolerant plants mixed with El-Mufeed liquid. Blood samples were assembled from all experimental animals during dry, gestation and early lactation periods. Profile of MAD, TAC, CAT and trace elements (Cu, Se, Mn and Zn) were analyzed in plasma, while antioxidant SOD and GPX activities were measured in erythrocytes. Oxidative stress marker (MAD) was increased significantly with progress of gestation and lactation period and the vice versa was observed in TAC, CAT, SOD and GPX. It was observed that trace element and antioxidant enzymes had similar trend of changing with experimental period. Goats fed salt tolerant plants treated with El-Mufeed liquid did not differ greatly than control ones in their blood contents of antioxidant capacity (TAC) and antioxidant enzymes beside trace elements in spite of exposing to higher stress. Accordingly, it can be concluded that using El-Mufeed liquid to supply animals with trace minerals reduced oxidative effect of salt plants especially under stress of pregnancy.