A study was assigned to assess the ameliorate the feeding value of  jatropha seed meal by chemical or autoclave treatments and the feasibility of using in rabbit diets. Sixty weaned APRI rabbits, six weeks old with an average live body weight 707.26±4.54g were allotted randomly to five groups (twelve rabbits/treatment in 3 replicates). Five experimental diets were formulated where soybean meal protein of the basal diet (control) was replaced by chemically or autoclaved jatropha seed  meal protein (CTJSM   or ATJSM, respectively)  of the rate of  15 or 30%. The growth  trail continued lasted up to 14^th week of age. There were final body weight and   daily body weight gain with rabbits fed diets containing 15% CTJSM and 15% ATJSM diets  close to rabbis  fed control diets. The feed conversion ratio was significantly improved with 15% ATJSM and CTJSM diets compared with control. Digestion coefficients and nutritive values were insignificantly differed with tested diet contained 15% CTJSM compared to control. The control and tested groups resulted in the better dressing% compared to 30% CTJSM group. There were significantly increased in plasma ALT when replacing 15 or 30% ATJSM  and 15% CTJSM, while plasma AST was significantly decreased when rabbit fed 15 % ATJSM compared to control. Economic efficiency and relative economic efficiency recorded the highest values with 15% CTJSM followed by 15% ATJSM, compared to control.Conclusively, It could be concluded soybean meal protein could be replaced by CTJSM and ATJSM protein at the level of 15%without an adverse in rabbits performance.