This work was conducted to investigate the effect of ethanolic pomegranate peels (PP) extract on liver and kidney structure and function in rats experimentally exposed to different doses of aflatoxins (AFS). An experiment was conducted for 6 weeks, 36 male rats were divided into 6 groups (6 rats in each). G₁ served as vehicle treated control, G₂ received PP extract via gavage (50 mg/kg body weight (b.w.) daily). G₃ received AFS via gavage (1 mg/kg b.w.) twice/week. G₄ received AFS via gavage (2 mg/kg b.w.) twice/week. G₅ received AFS twice/week (1 mg/kg b.w.) + (PP) extract daily (50 mg/kg b.w.). G₆ received AFS twice/week (2 mg/kg b.w.) + (PP) extract daily (50 mg/kg b.w.). Liver enzymes (Alanine Amino Transferase (ALT), Aspartate Amino Transferase (AST), Alkaline Phosphatase (ALP)), Total Protein (TP), albumin and renal biochemical parameters (creatinine, urea and uric acid) were estimated in serum at 3^rd and 6^­­thweek post treatment , while pathological examination of liver and kidney was performed at the end of experiment. Result demonstrated that both aflatoxins administrated levels caused elevation in AST, ALT, ALP, creatinine, urea and uric acid and a decrease in TP and albumin in dose and time dependant manner, while synergistic administration of PP extract and AFS resulted in limitation of the negative effects of AFS on the tested parameters especially with low AFS dose and longer time. Pathological examination revealed that the severity of damage in liver and kidney correlated with aflatoxins^, doses. While PP extract administration was able to protect liver and kidney against low AFS dose and minimize the damage of liver and kidney induced by high AFS dose.