Hydrated Sodium Calcium Aluminosilicate (HSCAS) and Yeast (Saccharomyces  cerevisiae) cell wall  (YCW) were  evaluated for their  ability to reduce the deleterious effects of aflatoxin (AFT) on broiler performance. They were  incorporated singly or in combination into a diet containing total  AFT 211.88 µg  / kg feed . No significant changes  was recorded in all tested parameters ,body weight ( BW ), body weight gain ( BWG) , feed intake (FI)  and feed  conversion ( FC) ratio  during starter period . In growing period ,treated groups showing significant elevation in some recorded parameter , that in contrast with each other  or with control groups . In finisher periods , however no detectable pattern for changes was recorded , but the group which treated with  HSCAS only showing significant depletion in both BWG and  FI  , while that treated with it in AFT- contaminated diet showing significant elevation . The same significant elevation was recorded in BW ,BWG and FI for groups which treated with YCW , while liver weight of this groups was significantly decreased in relation to other groups .The highest mortality rate was recorded in group treated with AFT only , and that which treated with AFT  and YCW . The highest level of aflatoxin residue in litter of broiler was recorded in litter of group which treated with HSCAS singly, while the lowest was in group  treated with YCW only. The levels  of micro-elements  Al , As , Cd , Pd , Se , Cu, Fe ,Mn, Zn  and macro-elements k , Na ,Mg  in broiler litter of different tested groups were also affected . The present study concluded  that, no clear improvements in the tested parameters were recorded after the  the contaminated diets were  incorporated with the tested dose of HSCAS  and YCW , singly or in combination ,during aflatoxicosis . Also , in part , focused the unwanted behavioral of adsorbents in animal production, and submitted  that the using of this materials in animal feed must be restricted , because of its unknown undesired effects , as well as  its indirect dangerous effect in livestock.