Hydrated Sodium Calcium Aluminosilicate (HSCAS) and Yeast (Saccharomyces  cerevisiae) cell wall  (YCW) were  evaluated for their  ability to reduce the deleterious effects of aflatoxin (AFT) in broiler diets. They were  incorporated singly or in combination into a diet containing total  AFT 211.88 µg  / kg feed. Aflatoxin  induced  vacuolar degeneration of hepatocytes, thickening in the wall of bile duct associated with leucocytic cells infiltration in the portal triad, kidneys showed necrobiotic changes of renal tubular epithelium with pyknosis of their nuclei and hypercllularity of glomerular tufts. Brain of chickens showed more or less similar histopathological changes described as necrosis of neurons , neuronophagia of necrotic neurons and necrosis of purkinje cells of the cerebellum .The levels of AFT residue in the treated  groups were varied in type and amount from group to group as well as from tissue to tissue. Also  aflatoxin induced an  elevation in the levels of the elements  AS , Pb  and Zn  in the tested tissues. Slight histopathological improvement was recorded in the previous tissues after the contaminated diet was  incorporated singly or in combination with HSCAS and YCW. The most noticeable record was the drastic elevation in level of Al in  the tissues of  groups which were treated with  HSCAS. The same groups revealed higher levels of AFT residue in meat and liver .Theaddition of  YCW didn't induce noticeable improvement. Data concluded  that, no clear improvements in the tested parameter were recorded after the contaminated diets were  incorporated with the recommended dose of HSCAS  and YCW , singly or in combination, during aflatoxicosis. More specific researchis needed to clarify   their unknown undesired effects on broiler.