New born lambs are facing many environmental challenges that are totally different from the uterus one. Adaptation to extra-uterine life involves functional changes with almost each organ and system in the body undergoing a series of metabolic and anatomical modifications. Thirty healthy Barki ewes (3-4 years old) with average live body weight of 40±0.2 kg were used in the present study. This study aimed to investigate the effect of dietary supplementation with calcium soaps of poly unsaturated fatty acids (CSFA) on adaptive traits for ewes and their new lambs during pre and after parturition. Total protein (TP), albumin (Al), total lipids (TL) high density lipoprotein (HDL), triglycerides (TG), and cholesterol (CHOL) were investigated. Lamb's sex ratio of 32 lambs born, control dams had 7 females vs. 7 males compared to 13 females vs. 5 males for CSFA supplemented ewes. Total protein of ewes in late of pregnancy was decline however increased after parturition (6.7 and 6.8 vs. 6.88 and 7.6) for control and treated group, respectively. The decrease in serum TP recorded from the mid (3^rd month) to the end of pregnancy could be attributed to the increased required of fetus from nutrient for purpose of growth and development. Results revealed that serum CHOL concentration were significantly (P<0.05) higher in treated group than control (85.6 and 84.2 Vs 141.2 and 80.6), respectively. Lipid metabolites including TG, LDL and HDL were significant increased and take the same trend of cholesterol during treatment period. Serum glucose was elevated but not significant whereas, serum TL, and Gl concentration were significantly (P<0.05) higher in treated group compared with control group. It is therefore essential that supplementation CSFA improve performance of ewes and the physiological response, which may have beneficial effects on lambs survival. Further evidence was required to study their influence on sex ratio and twining rate.