The present study aimed to investigate the effect of dietary graded levels of Aqua Superzyme, Garlen Allicin, and Diamond V (Original XPC) on the growth performance and economic production of Nile tilapia fish (10 g initial bodyweight) for 16 weeks in indoor feeding experiment. The obtained results revealed that the best treatment was the probiotic Diamond V- Original XPC at 0.5 % of the diet which was responsible for the significantly (P ≤ 0.05) best final bodyweight, total bodyweight gain, relative growth rate, specific growth rate, survival rate, condition factor (based on total length), return and economic efficiency among all tested materials and levels. So. It is recommended to use the feed additive Diamond V-Original XPC at 0.5% of the Nile tilapia diet for improving the growth performance, survival, and production economy.