This experiment was conducted to evaluate the efficiency of using two levels of vitamin E (vit.E) and C (vit.C) either alone or in combination as a feed additive to ameliorate the deleterious effects of Aflatoxin (AF) on broiler performance. A total of 280 one-day old un-sexed Ross broiler chicks were housed in batteries, randomly divided into ten experimental groups as follows: The first group (C) was fed on basal diet (Control), whereas, the rest groups were received the contaminated diet with AF at 1.2 ppm/kg diet where, C⁺: fed the contaminated diet, E₁₀₀:fed the contaminated diet with 100 mg vit.E/kg diet (E₁), E₂₀₀: fed the contaminated diet with 200 mg vit.E/kg diet (E₂), C₂₅₀: fed the contaminated diet with 250 mg vit.C/kg diet (C₁), C₅₀₀: fed the contaminated diet with 500 mg vit.C/kg diet (C₂), E₁₀₀C₂₅₀: fed the contaminated diet with E₁ + C₁, E₁₀₀C₅₀₀: fed the contaminated diet with E₁ + C₂, E₂₀₀C₂₅₀: fed the contaminated diet with E₂ + C₁ and E₂₀₀C₅₀₀: fed the contaminated diet with E₂ + C₂. The results indicated that, as expected, that C⁺ group had significantly lower final body weight and total body weight gain; worse total feed conversion ratio and higher total mortality rate than those of the C group. On the other hand, birds which received contaminated diet with combination of vit.E and vit.C supplementation (E₁₀₀C₂₅₀, E₁₀₀C₅₀₀, E₂₀₀C₂₅₀ and E₂₀₀C₅₀₀) had significantly an improvement in productive performance as compared to those received contaminated diet (C⁺). Moreover, there were no significant differences in productive performance among the birds which received control diet and those fed the contaminated diet plus combination of vit.E and C addition. Therefore, it could be concluded that supplemental diets with the combination of vit.E and C can be used as antitoxin when the diet contaminated with aflatoxin.