To evaluate the effects of different dietary levels of two feed additives, mainly Super Biobuds (P₁) and Bio-yeast (P₂).This laboratory study was carried out for 12 weeks. Each probiotic was tested at 3 levels, being 0.5, 1.0, and 1.5 g/kg diet. Each level was presented in 3 replicates. Twenty one glass aquaria (each of 60X75X50 cm and180 l water volume). Each aquarium was stocked by 10 African catfish fingerlings and fed daily at 3% of the biomass for 6 days a week. The obtained results could be summarized in the followings: 1) The use of probiotics in the diet of African catfish was better than the control (without additives) concerning the growth, feed utilization, and serum proteins of the fish. 2) The best fish growth was obtained using 1.0 and 1.5 from P₂, and 1.5 g/kg from P₁, respectively. 3) The use of such probiotics was responsible for increasing the crude protein percentage in the African catfish body, where the highest protein content was found by feeding 1.0, 1.5, and 1.5 g/kg diet of P₂, P₂, and P₁, respectively. So, it is to recommend the addition of 1.5 g/kg Bio-yeast (P2) to the African catfish diet to obtain fish with high protein content and low fat content; hence, leads to improvement in cultured fish performance and its quality.