The present work was carried out to investigate the effect of ZOR Roscoe (ZOR), AML L (AML) and their mixture on some physiological parameters and kidney structure of male albino rats. This study was undertoken in the animal house belong to Animal Production Department, Faculty of Agriculture, Al-Azhar University. Twenty-four male albino rats with an average body weight 100-130 g. The animals were divided into 4 similar groups group₁ (Control untreated group), group₂, ( rats fed with diet contain 5% ZOR Roscoe),  group₃ (rats fed on diet contain 5% AML L) and group₄ (rats fed on diet containg 2.5% ZOR Roscoe +2.5% AML L.). During the whole experimental period blood samples were collected and serum was analyzed for concentration of glucose, cholesterol, triglyceride  , urea and criatinin. At the end of the experiment, rats were scarificed to obtain the kidneys. Results indicated that treatment of rats with zingiber officinal and AML for 8 Weeks showed mild ischemic charges of some glomeruli and tubules in the cortex of the kidney, Meanwhile mix with zingiber officinal and AML showed minimal ischemic changes of some glomeruli and tubules in the cortex of the kidney. All medicinal plants treatment had hypochlosterolemic and hypolepidimic effects being the highest for the comparing treatment. Treatment of rats with medicinal plants for 8 weeks significantly increased serum urea and creatinine concentration.