Thirty six pregnant Rahmani ewes with an avg. 33.7 kg LBW and 3 years old age were used to investigate the effect of vitamin E daily supplementation to pregnant ewes at late gestation and early lactation on the productive performance and some biochemical blood constituents of treated ewes and their offspring's. Experimental animals were randomly assigned (28 days prepartum) to three nutritional groups; the 1st one served as a control (nil vitamin E supplement). The 2nd and 3rd groups were daily and individually administrated 400 IU of α-tocopherol acetate (vitamin E), 28 days prepartum (T1) and for 28 days pre and 28 days postpartum (T2). Experimental animals were offered their daily requirements during pregnancy and early lactation according to (NRC recommendations, 1985). Blood samples were routinely withdrawn from ewes and their offspring's to assess some blood measurements i.e. (GSH-Px), LDH, ALT, AST, Total protein and globulin fractions. Results obtained indicated that, Vitamin E supplementation to pregnant ewes during late gestation led to affect significantly (p<0.05) ewes and lambs (GSH-Px) enzyme activity, increase (p<0.05) serum total protein and globulin concentration value in favor of the two supplemented ewes groups and the corresponding offspring's. However, non-significant differences (p<0.05) in LDH enzyme concentration was detected. Liver enzyme activity i.e. ALT and AST indicated significant differences (p<0.05), indicating higher (p<0.05) values for both the two supplemented groups in comparison with the control ewes group and their lambs.