Milk production & composition and some blood parameters were examined in Egyptian buffaloes as affected by supplemented basal diet by crushed Fenugreek seeds. Sixteen lactating buffaloes aged 5-7 years (at the third and fifth seasons of lactation); 45 days from calving were divided into four dietary treatments, 4 animals per each. Buffaloes were fed individually on basal diet ration [concentrate feed mixture (CFM) and rice straw (RS)] according to developing of body weight and milk production during the whole experimental periods. The crushed Fenugreek seeds were given as feed additives to the basal ration at a level 100, 150 and 200 g/buffalo/ day for 2^nd, 3^rd and 4^th treatments, respectively, while the 1^st treatment considered as control.The results indicated that the dry matter intake (DMI) was significantly (P<0.05) increased in T₃ and T₃ than other groups. Also, crushed fenugreek seeds significantly(P<0.05) increased nutrient digestibilities (DM, OM, CP and EE). The total milk yields were 806.4, 896.0, 952.0 and 907.2 Kg, respectively. Also, the overall daily milk yield was 7.2, 8.0, 8.5 and 8.1 Kg/h/d for T₁, T₂, T₃ and T₄, respectively. Lactose percentage significantly (P<0.05) increased in treated buffaloes. However, fat percentage was significantly (P<0.05) decreased with treated buffaloes. The calculated efficiency of milk yield/DMI was increased (P<0.05) in Fenugreek treated buffaloes. The addition of crushed Fenugreek seeds increased (P<0.05) the level of blood plasma prolactin and GPT in lactating buffaloes.It could be concluded that adding fenugreek seeds to buffalo's rations at 100, 150 and 200 g /buffalo/day led to raising economic efficiency by about 6.6, 3.95 and 7.89 %, respectively and it could be recommended to improve feed efficiency, milk yield and economic efficiency.