This research work was carried out to investigate the effect of using Sesame seeds in goats rations on some rumen parameters, blood profile, feed utilization and growth performance of Zaraibi kids. Fifteen Zaraibi kids (17.53±0.24 kg live weight and 5 months old) were divided into 3 groups (5 kids each). The control group (G1) was fed a ration consisting of concentrate feed mixture (CFM) and corn silage (CS) according to NRC (1981) recommendation. Sesame seeds (SS) were used to replace 10 and 20% of total CP of rations for groups G2 and G3, respectively. The feeding trail lasted for 15 weeks. The obtained results showed that the daily DM intake tended to decrease (71.69, 67.24 and 68.01 g/kg w^0.75) as a result to substitution of CFM with SS in goat's rations (G1, G2 and G3, respectively). In the same time, the daily water consumption as ml/g/DM intake was  slightly higher with increasing level of SS in the rations. Concerning ruminal parameters, the effect of the experimental rations on ruminal pH values and ammonia-N concentration were not significant. But, ruminal total VFA's during 3 and 6 hrs post-feeding were significant as higher (P<0.05) with G2 and G3, compared with G1. The obtained results indicated also that most tested blood profile parameters were not significantly affected by tested experimental rations. Daily body gain (DBG) recorded the highest value (76.67 g) with G2 followed by G3 (72.62 g) and lastly G1 (65.00 g) and the differences were significant. The DBG increased by 17.95 and 11.72% with G2 and G3, respectively compared with control groups (G1). The best feed utilization efficiency based on DM was recorded with G2 (8.67) followed by G3 (9.01) in comparison with G1 (10.40). Moreover, the improvement in feed efficiency, based on CP, was 15.20 and 10.40% with two tested groups (G2 and G3, respectively) compared with control (G1). Thus, the feed economic efficiency was noticeably better (by 24.07%) as a result to using of SS at two tested levels 10 and 20% compared with control group.