This experiment was conducted to investigate the effect of the incubator system and broiler strain on broiler performance, carcass traits and economic evaluation. Total number of 900 hatchable eggs were distributed in a factorial arrangement 2×3 with 2 incubator system [multi stage (MS) and single stage (SS)] and three broiler strains [Cobb (CB), Avian (AV) and Indian River (IR)] totaling six groups with three replicates (50 eggs of each). After complete hatching, 180 unsexed broiler chicks one day-old were wing-banded, weighed individually and divided into at the same design into 18 floor pens according to their incubator system and strain. Live body weight, weight gain, feed consumption and feed conversion ratio were measured at 7, 14,  21, 28 and 35 days of age. Carcass traits, blood plasma constituents and economic efficiency were recorded at the end of trial (day 35). The broiler chicks produced from (SS) had significantly differences in live body weight, weight gain, feed consumption and feed conversion ratio than those produced from (MS). The same trend was observed in (AV) strain for these traits than the other strains (CB) and (IR).Carcass traits and blood plasma constituents showed insignificant figures in most parameters. Blood parameters showed insignificant figures in most parameters. However AST activity and A/G ratio have significant difference (P≤0.05) for (AV) strain and their interaction with incubator system (SS) than the other groups. The incubator system (MS) had highest net return and economic efficiency compared with the incubator system (SS). While, Avian broilers strain had the highest net return, economic efficiency and performance indexes compared to Cobb and Indian River broiler chick strains. These results conclude that the incubator system (single stage ) realize the best values of most productive performance traits, also Avian strain  was recorded higher productive performance compared with  as compared with Cobb and Indian River strains. The best economic efficiency and performance index were recorded for Avian broiler chicks strain which produced from incubator system (multi stage).