No studies have been published concerning to digestible energy and crude protein requirements for Native Middle-Egypt rabbits. The main objective of the current study was to determine the digestible energy (DE) and crud protein (CP) requirements for Native Middle-Egypt rabbits (NMER) to find out the optimum growth performance and economic efficiency. A total number of 78 Native Middle-Egypt rabbits (NMER) at 5 weeks of age (at weaning) were divided randomly into 6 groups with  three different crude protein levels; 13, 14.5 and 16% and  two levels of digestible energy; 2500 and 2350 kcal/kg diet in 3 X 2 factorial experiments for eleven weeks. Rabbits were housed in individual cages and kept under the same managerial conditions. Feed and water were offered ad libitum throughout the experimental period (5 to 16 weeks of age). Live body weight, feed intake and number of dead rabbits were recorded. Daily weight gain and feed conversion ratio were calculated. At 16 week four rabbits males were taken randomly from each treatment slaughtered to estimate some of carcass traits. Carcass parts were presented as a percent of live body weight. Data were statistically analyzed using the General linear Model Program of SAS. The differences between initial body weights (g) at 5 week of age in feeding groups were not significant. Two levels of digestible energy (DE) did not significant effects on all body weights expect at 8 week of age. Rabbits fed 14.5 protein % had body weight were heaviest in 8, 12 and 16 weeks of age.   Daily feed consumption in rabbits fed 14.5 protein % was higher significantly in 5-8 and 8-12 periods. Feed conversion was not significantly influenced by varying crude protein levels. In effects interaction digestible energy and crude protein levels, rabbits fed diets contains 14.5 % CP with 2500 kcal DE /kg diet had body weight were heaviest significantly in 8, 12 and 16 weeks of age. Daily weight gain in rabbits fed 14.5 protein % and 2500 kcal DE /kg, were higher than other groups during 5-8, 8-12 and 5-16 periods.Only during 5-8 period daily feed consumption was significantly influenced by varying digestible energy and crude protein levels .Diets contains 2500 kcal DE /kg diet and 14.5 % CP lead to improve feed conversion ratio during the period from 5 to 12 weeks compared to the other treatment but was not significantly. No significant differences between digestible energy levels were observed in total edible parts (TEP), Fore-quarter, hind-quarter and trunk while the weight of edible giblets (WEG) was significant different. From the economical point of view, the highest economic efficiency was recorded with rabbits fed diet containing 14.5% CP and 2350 kcal DE /kg diet and followed by that fed 13 % CP and 2350 kcal. The mortality % was zero in rabbits group fed on fed 2500 kcal with 14.5 % CP. The highest value of mortality %was observed for those groups were fed 16% CP with 2500 kcal DE/ kg and 13% CP with 2350 kcal DE/ kg. We could recommend with the diet containing fed 2500 kcal with 14.5 % CP for native rabbit during the growing period; from 5 to 16 weeks of age which was the best in economical view, body weight and growth performance in native Middle-Egypt rabbits.